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Nanoparticle Forming Polyelectrolyte Complexes Derived from Well-defined Block Copolymers by Sara E. Bakhtiari; Fanny Joubert; George Pasparakis; Steve Brocchini; Gareth R. Williams is a Materials Science article available to read on EtoBox.

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Polymers can be used in nanoparticle associated formulations to encapsulate cytotoxic drugs (e.g., paclitaxel). Polyelectrolyte complexes (PECs) that form drug associated colloids also have potential to form particulate associated formulations. We used RAFT polymerisation to prepare small families of narrow molecular weight distributed (i) methacrylate block co-polymers comprised of oligomeric ethylene glycol, poly(ethylene glycol) methyl ether methacrylate (PEGMA), and dimethyl amino pendent chains, 2-(dimethylamino) ethyl methacrylate (DMAEMA), and (ii) poly(methacrylic acid), PMAA. These polymers were examined for their ability to form PECs capable of drug encapsulation. Optimal control in RAFT polymerisation was confirmed by the linear increase of molecular weight and the narrow dispersity of the polymers (<1.2) as determined by 1H nuclear magnetic resonance and gel permeation chromatography. Dynamic light scattering and transmission electron microscopy showed formation of well-defined monodispersed nanoparticles with a hydrodynamic diameter of 25 ± 3 nm upon self-assembly of poly(PEGMA0.23-b-DMAEMA0.77)99 and PMAA75. These PECs are highly haemocompatible. Thin film hydration w

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Author

Sara E. Bakhtiari; Fanny Joubert; George Pasparakis; Steve Brocchini; Gareth R. Williams

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Materials Science (Physical Sciences)