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Nitric Oxide and Interleukin-8 as Inflammatory Components of Cystic Fibrosis by Caroline Francoeur; Michel Denis is a Immunology and Microbiology article available to read on EtoBox.

What is Nitric Oxide and Interleukin-8 as Inflammatory Components of Cystic Fibrosis about?

We examined the production of reactive nitrogen intermediates in the tracheo-bronchial tree of patients with cystic fibrosis (CF). Examination of the soluble phase of sputa from 17 CF patients revealed the presence of high levels of NO2/NO3 assayed by the Greiss reaction. We also examined the presence of the chemotactic cytokine interleukin-8 (IL-8) in these samples so as to assess another important inflammatory marker; high levels of IL-8 were present in the sputa of cystic fibrosis subjects. The elevated nitrite was not produced by the presence of Pseudomonas bacteria in the sputa, inasmuch as bacteria in culture released undetectable amounts of nitrite in culture media. Neutrophils from the sputa of CF patients with disease exacerbation released higher amounts of nitrite and IL-8. Neutrophils from the sputa were also shown to spontaneously release substantial amounts of nitrite in the supernatants, and this release was partly blocked by the antagonist N~-monomethyl-L-arginine (L-NMMA). Blood neutrophils were shown to release nitrite only in response to challenge with CF-associated strains of Pseudomonas, and not exposure to cytokines. There was no significant differences in nitr

Who reads Nitric Oxide and Interleukin-8 as Inflammatory Components of Cystic Fibrosis?

Author

Caroline Francoeur; Michel Denis

Publisher

Springer; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0360-3997)

Published

1995

Language

EN

Field

Immunology and Microbiology (Life Sciences)