Can I read Inhibitory effect of β-asarone, a component of Acorus calamus essential oil, on inhibition of adipogenesis in 3T3-L1 cells on EtoBox?

Inhibitory effect of β-asarone, a component of Acorus calamus essential oil, on inhibition of adipogenesis in 3T3-L1 cells by Meng-Hwan Lee; Yun-Yu Chen; Jung-Wei Tsai; Sheue-Chi Wang; Takashi Watanabe; Ying-Chieh Tsai is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Inhibitory effect of β-asarone, a component of Acorus calamus essential oil, on inhibition of adipogenesis in 3T3-L1 cells about?

Acorus calamus (Araceae) has been incorporated into traditional medicines and used in food supplements for hundreds of years. The aim of this study was to investigate the inhibitory effects of A. calamus essential oil (calamus oil) on the differentiation of 3T3-L1 preadipocytes into adipocytes. The major anti-adipogenic component of calamus oil was purified and identified as b-asarone. b-Asarone significantly inhibited intracellular lipid accumulation during adipocyte differentiation in a concentration-dependent manner. In addition, the protein and mRNA expression levels of C/EBPb, C/EBPa, and PPARc were decreased in 3T3-L1 cells treated with b-asarone during differentiation. Phosphorylation of ERK1/2, which is known to regulate the early phase of adipogenesis, was attenuated by b-asarone treatment. These results suggest that b-asarone exerts anti-adipogenic activity, in part by suppressing the expression of adipogenic transcription factors.

Who reads Inhibitory effect of β-asarone, a component of Acorus calamus essential oil, on inhibition of adipogenesis in 3T3-L1 cells?

Author

Meng-Hwan Lee; Yun-Yu Chen; Jung-Wei Tsai; Sheue-Chi Wang; Takashi Watanabe; Ying-Chieh Tsai

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0308-8146)

Published

2011

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)