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LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma by Lijun Li; Zhihao Wen; Ni Kou; Jing Liu; Dong Jin; Lina Wang; Fu Wang; Lu Gao is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Salivary gland adenoid cystic carcinoma (SACC) is one of the most common malignant tumors, with high aggressive potential in the oral and maxillofacial regions. Lissencephaly 1 (LIS1) is a microtubule-organizing center-associated protein that regulates the polymerization and stability of microtubules by mediating the motor function of dynein. Recent studies have suggested that LIS1 plays a potential role in the malignant development of tumors, such as in mitosis and migration. However, the role of LIS1 in SACC development and its related molecular mechanisms remain unclear. Thus, the effects of LIS1 on the proliferation, apoptosis, invasion and metastasis of SACC were studied, __in vivo__ and __in vitro__. The results of immunohistochemical staining showed that LIS1 was highly expressed in SACC tissues, and its expression level was associated with malignant progression. __In vitro__, the results of CCK-8, TUNEL, wound healing and Transwell assays demonstrated that LIS1 promotes proliferation, inhibits apoptosis, and enhances the migration and invasion of SACC-LM cells. __In vivo__, knockdown of LIS1 effectively suppressed the growth of subcutaneous tumors in a mouse xenograft and d

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Author

Lijun Li; Zhihao Wen; Ni Kou; Jing Liu; Dong Jin; Lina Wang; Fu Wang; Lu Gao

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)