About this Medicine article
The future of cancer immunotherapy: DNA vaccines leading the way by Aanshi Pandya; Yesha Shah; Nirjari Kothari; Humzah Postwala; Aayushi Shah; Priyajeet Parekh; Mehul R. Chorawala is a Medicine article available to read on EtoBox.
Immuno-oncology has revolutionized cancer treatment and has opened up new opportunities for developing vaccination methods. DNA-based cancer vaccines have emerged as a promising approach to activating the bodily immune system against cancer. Plasmid DNA immunizations have shown a favorable safety profile and there occurs induction of generalized as well as tailored immune responses in preclinical and early-phase clinical experiments. However, these vaccines have notable limitations in immunogenicity and heterogeneity and these require refinements. DNA vaccine technology has been focusing on improving vaccine efficacy and delivery, with parallel developments in nanoparticle-based delivery systems and gene-editing technologies such as CRISPR/Cas9. This approach has showcased great promise in enhancing and tailoring the immune response to vaccination. Strategies to enhance the efficacy of DNA vaccines include the selection of appropriate antigens, optimizing insertion in a plasmid, and studying combinations of vaccines with conventional strategies and targeted therapies. Combination therapies have attenuated immunosuppressive activities in the tumor microenvironment and enhanced the c
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Aanshi Pandya; Yesha Shah; Nirjari Kothari; Humzah Postwala; Aayushi Shah; Priyajeet Parekh; Mehul R. Chorawala
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)