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A 2cM genome-wide scan of European Holstein cattle affected by classical BSE by Brenda M Murdoch; Michael L Clawson; William W Laegreid; Paul Stothard; Matthew Settles; Stephanie McKay; Aparna Prasad; Zhiquan Wang; Stephen S Moore; John L Williams is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract ## Background Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion protein of sheep or humans have been associated with variations in transmissible spongiform encephalopathy susceptibility or resistance. In contrast, there is no strong evidence that non-synonymous mutations in the bovine prion gene (__PRNP__) are associated with classical BSE disease susceptibility. However, two bovine __PRNP__ insertion/deletion polymorphisms, one within the promoter region and the other in intron 1, have been associated with susceptibility to classical BSE. These associations do not explain the full extent of BSE susceptibility, and loci outside of __PRNP__ appear to be associated with disease incidence in some cattle populations. To test for associations with BSE susceptibility, we conducted a genome wide scan using a panel of 3,072 single nucleotide polymorphism (SNP) markers on 814 animals representing cases and control Holstein cattle from the United Kingdom BSE epidemic. ## Results Two sets of BSE affected Holstein cattle were

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Author

Brenda M Murdoch; Michael L Clawson; William W Laegreid; Paul Stothard; Matthew Settles; Stephanie McKay; Aparna Prasad; Zhiquan Wang; Stephen S Moore; John L Williams

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2156)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)