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A Genome Scan of Neuroticism in Nicotine Dependent Smokers by Benjamin M. Neale; Patrick F. Sullivan; Kenneth S. Kendler is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A Genome Scan of Neuroticism in Nicotine Dependent Smokers about?

## Abstract Neuroticism is a personality factor that has consistently been demonstrated to be associated with anxiety, depression, and other “internalizing” disorders. We analyzed a genome scan for neuroticism on a sample of 129 sib‐pair families (113 with a single sibling pair, 18 with multiple sibling pairs) containing a total of 201 possible sibling pairs, ascertained for concordance on nicotine dependence. Using Merlin‐Regress, we replicated peaks for neuroticism described by prior studies, on chromosomes 1 and 11 with LOD scores of 2.52 and 1.97 (__P__‐value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (__P__‐value of 0.0014). © 2004 Wiley‐Liss, Inc.

Who reads A Genome Scan of Neuroticism in Nicotine Dependent Smokers?

Author

Benjamin M. Neale; Patrick F. Sullivan; Kenneth S. Kendler

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1552-4841)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)