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Derivatization Procedures for the Detection of Estrogenic Chemicals by Gas Chromatography/mass Spectrometry by Wang-Hsien Ding; Cheng-Che Chiang is a Chemistry article available to read on EtoBox.

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## Abstract This work evaluated derivatization procedures for detecting both natural and synthetic estrogenic chemicals by gas chromatography/mass spectrometry (GC/MS). Different silylating agents, mainly trimethylsilylating (TMS) agents, were compared, and the roles of various content of trimethylchlorosilane (TMCS, as a stimulator) were investigated. The difference in the abundances of the derivatives was caused by the steric hindrance of multiple hydroxyl groups and ethynyl groups in the structures of estrogenic chemicals. The use of TMCS produces an increase in the derivatization yield, especially for the compounds with multiple hydroxyl groups (i.e., 17β‐estradiol (E~2~) and estriol (E~3~)). Mass spectra of O‐TMS derivatives and tentative fragmentation profiles are proposed. Molecular ions were the base peaks for all the derivatives, and were used as the quantitation ions to obtain maximum detection sensitivity and specificity. Sample enrichment was achieved by Oasis® HLB solid‐phase extraction cartridges. The quantitation limits of these compounds ranged from 5 to 10 ng/L in 1000‐mL water samples. Recovery of the estrogenic chemicals in spiked various water samples ranged fro

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Author

Wang-Hsien Ding; Cheng-Che Chiang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0951-4198)

Published

2002

Language

EN

Field

Chemistry (Physical Sciences)