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A fatty acid-binding protein expression in the vector of Chagas’ disease by P.R.B. Bittencourt-Cunha; G.O. Paiva-Silva; M.H.F. Sorgine; G.C. Atella is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is A fatty acid-binding protein expression in the vector of Chagas’ disease about?

Fatty acid-binding proteins (FABP) are members of a superfamily of cytoplasmic hydrophobic ligand-binding proteins. In insects, gut lumen absorbs blood-derived free fatty acids (FFAs), converting them mainly to phospholipidis and diacylglycerols. The three main organs involved in lipid metabolism are: the midgut, responsible for the absorption; the fat body the lipid storage tissue; and the ovary, which is involved in egg formation. Thus, we are investigating the presence and expression of FABP in these tissues at different physiological situations. Adult females of Rhodnius prolixus were fed, their midguts were dissected, the RNA was extracted and analyzed by real time-PCR. FABP expression changes during blood digestion, in the midgut and fat body, but not in the ovaries, leading us to believe that another protein can be responsible for the transport of fatty acid in this organ. The expression of FABP was determined in insects infected with the parasite that causes Chagas disease, Trypanosoma cruzi. The expression of FABP was 7 times higher in the midgut infected with T. cruzi in the first day after feeding. FABP expression was altered even in organs that do not have contact with

Who reads A fatty acid-binding protein expression in the vector of Chagas’ disease?

Author

P.R.B. Bittencourt-Cunha; G.O. Paiva-Silva; M.H.F. Sorgine; G.C. Atella

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-3084)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)