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Selective C−C Bond Cleavage Method by tw-666 is a document available to read on EtoBox.
The article presents a method for the selective oxidative cleavage of the C−C bond in α,β-epoxy ketones to produce aromatic carbonyl compounds using tert-butanol hydroperoxide (TBHP) as an oxidant. The reaction yields aromatic aldehydes and acids in moderate to good yields, with the highest HPLC yield of aromatic aldehyde reaching 91%. The study discusses the reaction mechanism, substituent effects, and the potential for metal-free reactions.
- Author
- tw-666
- Language
- EN