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Targeting MMPs in Acute and Chronic Neurological Conditions by V. Wee Yong; Smriti M. Agrawal; David P. Stirling is a Medicine article available to read on EtoBox.

What is Targeting MMPs in Acute and Chronic Neurological Conditions about?

The matrix metalloproteinases (MMPs) are important enzymes that regulate developmental processes, maintain normal physiology in adulthood and have reparative roles at specific stages after an insult to the nervous system. Conversely, the concordant presence and significant upregulation of several MMP members in virtually all neurological conditions result in pathology. Thus, the MMPs have diverse functions, capable of mediating repair and recovery on the one hand and being involved in producing injury on the other. Therefore, targeting MMPs in neurological conditions has become a complicated challenge. This article highlights the beneficial roles of MMPs in normal and reparative processes within the nervous system and discusses the detriments of MMPs encountered in pathology. We review the availability of MMP inhibitors for clinical use and propose that an important consideration for these inhibitors is timing and duration of their use. With acute injuries where a massive upregulation of several MMPs are observed in the early periods after the insult, early and short-term use of broad spectrum MMP inhibitors would seem logical. In chronic conditions where recurrent insults to the C

Who reads Targeting MMPs in Acute and Chronic Neurological Conditions?

Author

V. Wee Yong; Smriti M. Agrawal; David P. Stirling

Publisher

Springer-Verlag; Springer New York LLC; Springer Science and Business Media LLC (ISSN 1933-7213)

Published

2007

Language

EN

Field

Medicine (Health Sciences)