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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2 by Attila Garami; Fried J.T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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with this, studies in Drosophila and in mammals demonfor Biomedical Research strate that TSC1/2 acts to constrain both mitogen-and Maulbeerstrasse 66 nutrient-induced activation of the mTOR/S6K/4E-BP 4058 Basel signal transduction pathway (Marygold and Leevers, Switzerland 2002; McManus and Alessi, 2002), which has been impli-2 Department of Physiological Chemistry and cated in the progression of a number of solid tumors Centre for Biomedical Genetics Universiteitsweg (Abraham, 2002; Hidalgo and Rowinsky, 2000; Sekulic 100 3584 CG Utrecht et al., 2000). At least in part, TSC1/2 repression of the The Netherlands mitogen-induced segment of the mammalian mTOR/ 3 Zoologisches Institut der Universita ̈t Zu ̈rich S6K/4E-BP signaling pathway appears to be relieved Winterthurerstrasse 190 by protein kinase B (PKB) phosphorylation of TSC2, a 8057 Zu ̈rich response mediated by insulin-induced activation of Switzerland phosphatidylinositide-3OH kinase (PI3K) (Goncharova et al., 2002; Inoki et al., 2002; Jaeschke et al., 2002; Manning et al., 2002). Moreover, hamartomatous lesions Summary are also observed in patients with one of three related autosomal-dominant disorders associated with ge

Who reads Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2?

Author

Attila Garami; Fried J.T Zwartkruis; Takahiro Nobukuni; Manel Joaquin; Marta Roccio; Hugo Stocker; Sara C Kozma; Ernst Hafen; Johannes L Bos; George Thomas

Publisher

Elsevier BV

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)