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Hydrophilic Polymer Drug from a Derivative of Salicylic Acid: Synthesis, Controlled Release Studies and Biological Behavior by Gema Rodríguez; Alberto Gallardo; Mar Fernández; Mercedes Rebuelta; Julia Buján; Juan M Bellón; Natalio G Honduvilla; Cristina Escudero; Julio San Román is a Materials Science article available to read on EtoBox.
What is Hydrophilic Polymer Drug from a Derivative of Salicylic Acid: Synthesis, Controlled Release Studies and Biological Behavior about?
## Abstract **Summary:** Hydrophilic polymeric drugs bearing “Triflusal” (4‐trifluoromethylsalicylic acid), a drug widely used as antithrombogenic agent (Disgren®), have been prepared by free radical copolymerization of methacryloyloxyethyl [2‐(acetyloxy)‐4‐(trifluoromethyl)] benzoate (HTRF) and __N__,__N__′‐dimethylacrylamide (DMA). The reactivity ratios of both monomers have been determined by ^1^H NMR spectra by applying non‐linear least square treatments to the copolymerization equation (terminal model), and the kinetic parameters obtained indicated that the microstructure of copolymer chains is homogeneous, with a random distribution of the active HTRF units along the copolymer chains. That means that for the copolymer system THDMA22 used in this work, HTRF units are mainly isolated in relatively long DMA sequences. Therefore, in this structure the intramolecular interactions between adjacent HTRF units are negligible. Release of Triflusal from THDMA22 has been studied in vitro using buffered solutions at pH = 2, 7.4 and 10 and 37 °C. The system showed an interesting pseudo‐zero order release profile at pH = 7.4 during several months. It has been also evaluated the pharmacolog
Who reads Hydrophilic Polymer Drug from a Derivative of Salicylic Acid: Synthesis, Controlled Release Studies and Biological Behavior?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Gema Rodríguez; Alberto Gallardo; Mar Fernández; Mercedes Rebuelta; Julia Buján; Juan M Bellón; Natalio G Honduvilla; Cristina Escudero; Julio San Román
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)
- Published
- 2004
- Language
- EN
- Field
- Materials Science (Physical Sciences)