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Picornaviruses: A View from 3A by Jackson, Terry (author);Belsham, Graham J. (author) is a Medicine article available to read on EtoBox.

What is Picornaviruses: A View from 3A about?

Picornaviruses are comprised of a positive-sense RNA genome surrounded by a protein shell (or capsid). They are ubiquitous in vertebrates and cause a wide range of important human and animal diseases. The genome encodes a single large polyprotein that is processed to structural (capsid) and non-structural proteins. The non-structural proteins have key functions within the viral replication complex. Some, such as 3D pol (the RNA dependent RNA polymerase) have conserved functions and participate directly in replicating the viral genome, whereas others, such as 3A, have accessory roles. The 3A proteins are highly divergent across the Picornaviridae and have specific roles both within and outside of the replication complex, which differ between the different genera. These roles include subverting host proteins to generate replication organelles and inhibition of cellular functions (such as protein secretion) to influence virus replication efficiency and the host response to infection. In addition, 3A proteins are associated with the determination of host range. However, recent observations have challenged some of the roles assigned to 3A and suggest that other viral proteins may carry

Who reads Picornaviruses: A View from 3A?

Author

Jackson, Terry (author);Belsham, Graham J. (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)