Can I read Efficient Treatment of Heterogeneous Malignant Cell Populations on EtoBox?

Efficient Treatment of Heterogeneous Malignant Cell Populations by Harush, Uzi; Straussman, Ravid; Barzel, Baruch is a scholarly article available to read on EtoBox.

What is Efficient Treatment of Heterogeneous Malignant Cell Populations about?

When confronted with an undesired cell population, such as bacterial infections or tumors, we seek the most effective treatment, designed to eliminate the population as rapidly as possible. A common practice is to monitor the cells short-term response to the treatment, and from that, extrapolate the eventual treatment outcome, i.e. will it eradicate the cells, and if yes at what timescales. Underlying this approach is the assumption that the cells exhibit a homogeneous response to the treatment, and hence the early response patterns can be naturally extended to later times. Recent experiments on cancer cell populations, however, indicate a significant level of cellular heterogeneity, undermining this classic assessment protocol of treatment efficacy. We, therefore, develop here a stochastic framework, to analytically predict the temporal dynamics of a heterogeneous cell population. Quite often, we find, the average cellular parameters, governing the short-term response, fail to predict the actual treatment outcome. In contrast, our analysis, which also incorporates the populations variability, helps identify the relevant statistical parameters, which in turn, enable us to predict t

Author

Harush, Uzi; Straussman, Ravid; Barzel, Baruch

Published

2025

Language

EN