Can I read Two Different Serologic Mechanisms of Paroxysmal Cold Hemoglobinuria, Illustrated by Three Cases on EtoBox?

Two Different Serologic Mechanisms of Paroxysmal Cold Hemoglobinuria, Illustrated by Three Cases by VAN LOGHEM, J. J.; DE LEON, D. E. MENDES; FRENKEL-TIETZ, HERTA; VAN DER HART, MIA is a Medicine article available to read on EtoBox.

What is Two Different Serologic Mechanisms of Paroxysmal Cold Hemoglobinuria, Illustrated by Three Cases about?

Abstract During the last years many examples of paroxysmal cold hemoglobinuria have been described in which attention has been given to the serologic differentiation into two groups, the one (group A) characterized by a biphasic hemolysin, the other (group B) marked by the presence of cold aggluitinin in a very high titer, as was summarized in the report of Becker.3 We should like to stress that the hemolysins of group A, though all of the biphasic type, show many variations as far as concerns thermostability, optimal period of the cold phase and the need of complement for the fixation of the antibody in the cold. In our own case the hemolysin behaved differently from those earlier described in that it reacted only with the patient’s cells and not with others. In addition it was found that the hemolysin reacted with P.N.H. cells as a monophasic warm antibody. Next to the hemolysin an incomplete cold antibody of an unusual type was present in the serum of the patient. It is suggested that this antibody is not identical with the hemolysin and of minor importance for the hemolytic process. In group B the cold agglutinins predominated, but apart from these a monophasic warm hemolysin c

Who reads Two Different Serologic Mechanisms of Paroxysmal Cold Hemoglobinuria, Illustrated by Three Cases?

Author

VAN LOGHEM, J. J.; DE LEON, D. E. MENDES; FRENKEL-TIETZ, HERTA; VAN DER HART, MIA

Publisher

American Society of Hematology (ISSN 0006-4971)

Published

1952

Language

EN

Field

Medicine (Health Sciences)