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Peripheral Involvement in Nicotine-induced Enhancement of Ethanol Intake by Mia Ericson; Jörgen A Engel; Bo Söderpalm is a Medicine article available to read on EtoBox.
What is Peripheral Involvement in Nicotine-induced Enhancement of Ethanol Intake about?
It is a well-known fact that a large percentage of alcoholics smoke, and in the experimental rat, intermittent nicotine administration enhances ethanol intake and ethanol preference in a free-choice situation between 6% (v/v) ethanol and water. The present study focuses on the possible involvement of central and/or peripheral nicotine acetylcholine receptors (nAChR) in nicotine-induced sensitization to dopamine-related behavioral effects of ethanol. Wistar rats drinking less than 60% of their total daily fluid from a 6% ethanol solution were used in the study. Nicotine, vehicle, mecamylamine, hexamethonium, mecamylamine+nicotine, and hexamethonium+nicotine were administered subchronically for 15 days. All groups, except the vehicle pre-treated group, markedly increased their ethanol preference to approximately 80%, as well as their ethanol intake. NMRI mice received the same treatments for 10 days, after which ethanol (2.5 g/kg, intraperitoneal (i.p.)) was given acutely and locomotor activity was recorded. Ethanol-induced locomotor stimulation was enhanced in most groups, as compared to the vehicle pre-treated group. Administration of quarternary autonomic drugs to ethanol high-pre
Who reads Peripheral Involvement in Nicotine-induced Enhancement of Ethanol Intake?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mia Ericson; Jörgen A Engel; Bo Söderpalm
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)