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Dialysis-related Carpal Tunnel Syndrome in the Past 40 Years by Masaki Hatano; Izuru Kitajima; Seizo Yamamoto; Masaki Nakamura; Kazuya Isawa; Tatsuya Suwabe; Junichi Hoshino; Naoki Sawa; Yoshifumi Ubara is a Medicine article available to read on EtoBox.

What is Dialysis-related Carpal Tunnel Syndrome in the Past 40 Years about?

## Abstract ## Purpose and method Patients on hemodialysis develop carpal tunnel syndrome (CTS) due to an accumulation of dialysis-related β2 microglobulin (β2m) amyloid (DRA). In Japan, dialysis technology has progressed remarkably in the past 40 years and has increased the time until patients require surgery for CTS. However, unclear is whether the time from the start of hemodialysis to the first surgery for CTS is associated with β2m clearance by the different hemodialysis techniques. Therefore, we retrospectively evaluated β2m clearance, serum β2m levels, and the change in the length of this period in patients across 4 periods according to the year that first surgery for CTS was performed: period 1, 1982–1989; period 2, 1990–1999; period 3, 2000–2009; and period 4, 2010–2019. ## Result A total of 222 patients who met the selection criteria were included. Mean β2m clearance was −1.8 ± 16.7% in period 1, and improved to 65.4 ± 8.6% in period 3. Accordingly, the serum β2m value after hemodialysis decreased significantly. The time from the start of hemodialysis to the first surgery for CTS was 12.4 ± 2.9 years in period 1 but increased to 21.8 ± 6.3 years in period 3. In multivaria

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Author

Masaki Hatano; Izuru Kitajima; Seizo Yamamoto; Masaki Nakamura; Kazuya Isawa; Tatsuya Suwabe; Junichi Hoshino; Naoki Sawa; Yoshifumi Ubara

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)