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Imaging Changes Over 18 Months Following Stereotactic Radiosurgery for Brain Metastases: Both Late Radiation Necrosis and Tumor Progression Can Occur by Dylann Fujimoto; Rie von Eyben; Iris C. Gibbs; Steven D. Chang; Gordon Li; Griffith R. Harsh; Steven Hancock; Nancy Fischbein; Scott G. Soltys is a Medicine article available to read on EtoBox.

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Following stereotactic radiosurgery (SRS) for brain metastases, the median time range to develop adverse radiation effect (ARE) or radiation necrosis is 7-11 months. Similarly, the risk of local tumor recurrence following SRS is 18 months after SRS) tumor recurrence and late ARE, which have not previously been well described. An IRB-approved, retrospective review identified patients treated with SRS who developed new MRI contrast enhancement > 18 months following SRS. ARE was defined as stabilization/shrinkage of the lesion over time or pathologic confirmation of necrosis, without tumor. Local failure (LF) was defined as continued enlargement of the lesion over time or pathologic confirmation of tumor. We identified 16 patients, with a median follow-up of 48.2 months and median overall survival of 73.0 months, who had 19 metastases with late imaging changes occurring a median of 32.9 months (range 18.5-63.2 months) after SRS. Following SRS, 12 lesions had late ARE at a median of 33.2 months and 7 lesions had late LF occurring a median of 23.6 months. As patients with cancer live longer and as SRS is increasingly utilized for treatment of brain metastases, the incidence of these p

Who reads Imaging Changes Over 18 Months Following Stereotactic Radiosurgery for Brain Metastases: Both Late Radiation Necrosis and Tumor Progression Can Occur?

Author

Dylann Fujimoto; Rie von Eyben; Iris C. Gibbs; Steven D. Chang; Gordon Li; Griffith R. Harsh; Steven Hancock; Nancy Fischbein; Scott G. Soltys

Publisher

Springer Science and Business Media LLC

Published

2017

Language

EN

Field

Medicine (Health Sciences)