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What is Aza-Reformatsky Reaction via Photocatalysis about?
This document presents a novel approach to enantioselective aza-Reformatsky reactions using visible light and chiral Lewis acid catalysis, eliminating the need for reductants. The method enables the formation of chiral β-amino ketones with a gem-difluorine moiety through a radical coupling process, supported by various mechanistic studies. The research demonstrates successful substrate scope and potential applications in organic synthesis, including modifications of drug compounds.
- Author
- 1341835113
- Language
- EN