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This study utilizes integrated single-cell RNA sequencing and ATAC sequencing to analyze over 80,000 breast tissue cells, revealing distinct cancer cell states and a heterogeneity-guided core signature in tamoxifen-resistant breast cancer. The research identifies nine cancer cell states and a core signature of 137 genes, with BMP7 being validated as an oncogenic factor influencing tamoxifen resistance. The findings enhance understanding of tumor heterogeneity and suggest potential therapeutic targets to ove

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2789907076

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EN