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Prophylactic and therapeutic enoxaparin during pregnancy: Indications, outcomes and monitoring by Janet A Rowan; Claire McLintock; Rennae S Taylor; Robyn A North is a Medicine article available to read on EtoBox.

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## Abstract **Objectives:** To evaluate the efficacy and safety of prophylactic and therapeutic enoxaparin in pregnancy. **Study design:** Three‐year prospective audit. **Setting:** Tertiary level obstetric hospital. **Population:** Fifty‐two women who received subcutaneous enoxaparin, either a prophylactic dose (40 mg daily) in 26 pregnancies or therapeutic dose (1 mg/kg twice daily) in 32 pregnancies. **Materials and methods:** Pregnant women treated with enoxaparin were prospectively entered into a register. Data were retrieved by case note review. **Main outcome measures:** Pregnancy outcomes, treatment complications and anti‐Xa levels. **Results:** In the prophylactic group there were no fetal losses, thromboembolic events or complications related to enoxaparin. In the therapeutic group there were four first trimester miscarriages, a termination and 27 live births. Therapeutic enoxaparin prevented further thromboembolism without complications. One woman was treated with intermediate dose enoxaparin when she presented at 5 weeks’ gestation on warfarin and 7 weeks after a venous thromboembolism. She developed a recurrent pulmonary embolus 3 weeks later and was subsequently treat

Who reads Prophylactic and therapeutic enoxaparin during pregnancy: Indications, outcomes and monitoring?

Author

Janet A Rowan; Claire McLintock; Rennae S Taylor; Robyn A North

Publisher

Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley; Research Square (ISSN 0004-8666)

Published

2003

Language

EN

Field

Medicine (Health Sciences)