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Hyperhomocysteinemia Is Not Associated with Reduced Bone Quality in Humans with Hip Osteoarthritis by Joerg H. Holstein; Markus Herrmann; Christina Splett; Wolfgang Herrmann; Patric Garcia; Tina Histing; Moritz Klein; Karsten Kurz; Thomas Siebel; Tim Pohlemann; Michael D. Menger is a Medicine article available to read on EtoBox.
What is Hyperhomocysteinemia Is Not Associated with Reduced Bone Quality in Humans with Hip Osteoarthritis about?
## Abstract **Background:** Recent clinical and animal studies suggest that increased serum homocysteine (HCY) concentrations may be a risk factor for osteoporosis. In vitro studies showed that increasing HCY concentrations stimulate the activity of human osteoclasts. However, there is no data demonstrating that circulating HCY is related to structural and biomechanical properties of human bones. This study investigated the relationship between morphological as well as biomechanical bone properties and HCY serum concentrations in humans suffering from hip osteoarthritis (OA). **Methods:** Fasting blood samples and femoral heads were obtained from 94 males and females who underwent hip arthroplasty due to OA. Bones were assessed by dual energy X-ray absorptiometry (DXA), biomechanical testing (indentation method), and histomorphometry. Blood was collected for measurement of HCY, folate, vitamin B6, and vitamin B12. Subjects were classified as hyperhomocysteinemic (>12 μmol/L, n=47) and normohomocysteinemic (<12 μmol/L, n=47) according to their serum HCY concentrations. **Results:** Folate and vitamin B6, but not vitamin B12, were significantly lower in hyperhomocysteinemic subjects
Who reads Hyperhomocysteinemia Is Not Associated with Reduced Bone Quality in Humans with Hip Osteoarthritis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Joerg H. Holstein; Markus Herrmann; Christina Splett; Wolfgang Herrmann; Patric Garcia; Tina Histing; Moritz Klein; Karsten Kurz; Thomas Siebel; Tim Pohlemann; Michael D. Menger
- Publisher
- Walter de Gruyter GmbH
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)