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Association of TNF-α and IL-10 polymorphisms with tuberculosis in Tunisian populations by Walid Ben-Selma; Hedi Harizi; Jalel Boukadida is a Medicine article available to read on EtoBox.

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Cytokine Th1/Th2 balance is known to play a key role in controlling Mycobacterium tuberculosis infection. Based upon the functional role of the TNF-a [À308 G low / A high (rs1800629)] and IL-10 [À1082 A low / G high (rs1800870), À819 T low / C high (rs1800871) and À592 A low / C high (rs1800872)] single nucleotide polymorphisms (SNPs) on production levels, we genotyped 76 patients with pulmonary tuberculosis (TB) (pTB), 55 patients with extrapulmonary TB (epTB) and 95 healthy blood donors by polymerase chain reaction fragment length polymorphism (PCR-RFLP). We observed that À308 A allele was associated with increased risk susceptibility to epTB (OR 1⁄4 1.96; 95% CI, 1.04e3.71; P 1⁄4 0.024). The À1082 AG genotype was significantly associated with increased risk development of epTB (odds ratio [OR] 1⁄4 3.69; 95% confidence intervals [CI], 1.73e7.92; P corrected for the number of genotypes [Pc] 1⁄4 0.0003). By contrast, À1082 AA genotype appeared to be associated with resistance to pTB (OR 1⁄4 0.38; 95% CI, 0.19e0.74; Pc 1⁄4 0.006) and epTB (OR 1⁄4 0.22; 95% CI, 0.1e0.48; Pc 1⁄4 0.00006). High-producer IL-10 GCC haplotype seemed to be associated with 2.11-fold (95% CI, 1.28e3.46; Pc 1

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Author

Walid Ben-Selma; Hedi Harizi; Jalel Boukadida

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)

Published

2011

Language

EN

Field

Medicine (Life Sciences)