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Can I read Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series on EtoBox?
Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series by Singh, Siddharth; Chakravarty, Tarun; Chen, Peter; Akhmerov, Akbarshakh; Falk, Jeremy; Friedman, Oren; Zaman, Tanzira; Ebinger, Joseph E.; Gheorghiu, Mitch; Marbán, Linda; Marbán, Eduardo; Makkar, Raj R. is a Medicine article available to read on EtoBox.
What is Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series about?
There are no definitive therapies for patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Therefore, new therapeutic strategies are needed to improve clinical outcomes, particularly in patients with severe disease. This case series explores the safety and effectiveness of intravenous allogeneic cardiosphere-derived cells (CDCs), formulated as CAP-1002, in critically ill patients with confirmed coronavirus disease 2019 (COVID-19). Adverse reactions to CAP-1002, clinical status on the World Health Organization (WHO) ordinal scale, and changes in pro-inflammatory biomarkers and leukocyte counts were analyzed. All patients (__n__ = 6; age range 19–75 years, 1 female) required ventilatory support (invasive mechanical ventilation, __n__ = 5) with PaO~2~/FiO~2~ ranging from 69 to 198. No adverse events related to CAP-1002 administration were observed. Four patients (67%) were weaned from respiratory support and discharged from the hospital. One patient remains mechanically ventilated as of April 28th, 2020; all survive. A contemporaneous control group of critically ill COVID-19 patients (__n__ = 34) at our institution showed 18% overall mortality at a sim
Who reads Allogeneic cardiosphere-derived cells (CAP-1002) in critically ill COVID-19 patients: compassionate-use case series?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Singh, Siddharth; Chakravarty, Tarun; Chen, Peter; Akhmerov, Akbarshakh; Falk, Jeremy; Friedman, Oren; Zaman, Tanzira; Ebinger, Joseph E.; Gheorghiu, Mitch; Marbán, Linda; Marbán, Eduardo; Makkar, Raj R.
- Publisher
- Springer; Springer-Verlag; Dr. Dietrich Steinkopff Verlag; Springer Science and Business Media LLC (ISSN 0300-8428)
- Published
- 2020
- Language
- EN
- ISBN
- 9780039502003
- Field
- Medicine (Health Sciences)