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The effectiveness of COVID-19 vaccines against severe cases and deaths in Brazil from 2021 to 2022: a registry-based study by Santos, Cleber Vinicius Brito dos (author);Valiati, Naiara Cristina Morais (author);Noronha, Tatiana Guimarães de (author);Porto, Victor Bertollo Gomes (author);Pacheco, Antônio Guilherme (author);Freitas, Laís Picinini (author);Coelho, Flávio Codeço (author);Gomes, Marcelo Ferreira da Costa (author);Bastos, Leonardo Soares (author);Cruz, Oswaldo Gonçalves (author);Lana, Raquel Martins (author);Luz, Paula Mendes (author);Carvalho, Luiz Max Fagundes de (author);Werneck, Guilherme Loureiro (author);Struchiner, Claudio José (author);Villela, Daniel Antunes Maciel (author) is a Medicine article available to read on EtoBox.

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Background Brazil started the COVID-19 mass vaccination in January 2021 with CoronaVac and ChAdOx1, followed by BNT162b2 and Ad26.COV2.S vaccines. By the end of 2021, more than 317 million vaccine doses were administered in the adult population. This study aimed at estimating the effectiveness of the primary series of COVID-19 vaccination and booster shots in protecting against severe cases and deaths in Brazil during the first year of vaccination. Methods A cohort dataset of over 158 million vaccination and severe cases records linked from official national registries was analyzed via a mixed-effects Poisson model, adjusted for age, state of residence, time after immunization, and calendar time to estimate the absolute vaccine effectiveness of the primary series of vaccination and the relative effectiveness of the booster. The method permitted analysis of effectiveness against hospitalizations and deaths, including in the periods of variant dominance. Findings Vaccine effectiveness against severe cases and deaths remained over 25% and 50%, respectively, after 19 weeks from primary vaccination of BNT162b2, ChAdOx1, or CoronaVac vaccines. The boosters conferred greater protection th

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Author
Santos, Cleber Vinicius Brito dos (author);Valiati, Naiara Cristina Morais (author);Noronha, Tatiana Guimarães de (author);Porto, Victor Bertollo Gomes (author);Pacheco, Antônio Guilherme (author);Freitas, Laís Picinini (author);Coelho, Flávio Codeço (author);Gomes, Marcelo Ferreira da Costa (author);Bastos, Leonardo Soares (author);Cruz, Oswaldo Gonçalves (author);Lana, Raquel Martins (author);Luz, Paula Mendes (author);Carvalho, Luiz Max Fagundes de (author);Werneck, Guilherme Loureiro (author);Struchiner, Claudio José (author);Villela, Daniel Antunes Maciel (author)
Publisher
Elsevier BV
Published
2023
Language
EN
Field
Medicine (Health Sciences)

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