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1. Amino acids can be converted to specialized nitrogen-containing compounds like porphyrins and heme. Heme is an important prosthetic group containing an iron ion. 2. Heme is synthesized through a series of enzymatic reactions starting from glycine and succinyl CoA in the mitochondria, and continuing through the cytoplasm. Defects in heme synthesis can cause porphyrias, characterized by accumulation of porphyrin intermediates. 3. Porphyrias are classified as either hepatic or erythropoietic based on the

Author

Timothy George

Language

EN