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Modelling Columnarity of Pyramidal Cells in the Human Cerebral Cortex by Christoffersen, Andreas D.; Møller, Jesper; Christensen, Heidi S. is a scholarly article available to read on EtoBox.

What is Modelling Columnarity of Pyramidal Cells in the Human Cerebral Cortex about?

For modelling the location of pyramidal cells in the human cerebral cortex we suggest a hierarchical point process in $\mathbb{R}^3$ that exhibits anisotropy in the form of cylinders extending along the $z$-axis. The model consists first of a generalised shot noise Cox process for the $xy$-coordinates, providing cylindrical clusters, and next of a Markov random field model for the $z$-coordinates conditioned on the $xy$-coordinates, providing either repulsion, aggregation, or both within specified areas of interaction. Several cases of these hierarchical point processes are fitted to two pyramidal cell datasets, and of these a final model allowing for both repulsion and attraction between the points seem adequate. We discuss how the final model relates to the so-called minicolumn hypothesis in neuroscience.

Author

Christoffersen, Andreas D.; Møller, Jesper; Christensen, Heidi S.

Published

2019

Language

EN