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Effects of Atorvastatin on Inflammation and Oxidative Stress by Masaya Sugiyama; Masuo Ohashi; Hiroyuki Takase; Koichi Sato; Ryuzo Ueda; Yasuaki Dohi is a Medicine article available to read on EtoBox.

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Treatment with inhibitors of 3-hydroxyl-3methylglutaryl coenzyme A reductase (statins) reduces the incidence of cardiovascular events, but it is unclear whether the beneficial effects are mediated solely by their lipidlowering properties. We therefore investigated whether atorvastatin reduces inflammation and oxidative stress independently of its lipid-lowering effects. The subjects comprised 71 hyperlipidemic patients (64 Ϯ 9 years old, mean Ϯ SD) who were not receiving medical treatment. Serum lipid and C-reactive protein (CRP) levels, and urine 8-isoprostane level (an index of oxidative stress) were measured before and after 4 weeks of treatment with atorvastatin at 10 mg/day. In 38 patients, these biochemical variables and carotid intima-media thickness (IMT) were also measured after 6 months of treatment with atorvastatin. Atorvastatin markedly reduced CRP (from 0.69 Ϯ 0.36 to 0.42 Ϯ 0.20 and 0.35 Ϯ 0.19 mg/l, median Ϯ median absolute deviation, P Ͻ 0.0001), 8-isoprostane (from 225 Ϯ 99 to 178 Ϯ 75 and 179 Ϯ 60 ng/g creatinine, P Ͻ 0.05), and low density-lipoprotein cholesterol (LDLC; from 165 Ϯ 21 to 106 Ϯ 18 and 112 Ϯ 17 mg/dl, P Ͻ 0.0001) after 4 weeks and 6 months of treat

Who reads Effects of Atorvastatin on Inflammation and Oxidative Stress?

Author

Masaya Sugiyama; Masuo Ohashi; Hiroyuki Takase; Koichi Sato; Ryuzo Ueda; Yasuaki Dohi

Publisher

Springer Science and Business Media LLC

Published

2005

Language

EN

Field

Medicine (Health Sciences)