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Gadolinium(III) complexes of 1,4,7-triazacyclononane based picolinate ligands: simultaneous optimization of water exchange kinetics and electronic relaxation by Aline Nonat; Marion Giraud; Christelle Gateau; Pascal H. Fries; Lothar Helm; Marinella Mazzanti is a Chemistry article available to read on EtoBox.

What is Gadolinium(III) complexes of 1,4,7-triazacyclononane based picolinate ligands: simultaneous optimization of water exchange kinetics and electronic relaxation about?

The two new tripodal picolinate H 3 ebpatcn (1-carboxyethyl-4,7-bis((6-carboxypyridin-2-yl)methyl)-1,4,7-triazacyclononane) and H 4 pbpatcn (1-methylphosphonic-acid-4,7-bis((6-carboxypyridin-2-yl)methyl)-1,4,7-triazacyclononane) ligands based on the 1,4,7-triazacyclononane anchor were prepared and their lanthanide complexes were characterized by NMR, fluorescence and potentiometric studies. The [Gd(ebpatcn)(H 2 O)] complex displays a relaxivity of r 1 = 4.68 mM -1 s -1 at 45 MHz and 298 K, whereas r 1 = 4.55 mM -1 s -1 was measured for [Gd(Hpbpatcn)(H 2 O)] under the same conditions. The modified scaffold of the ligands with respect to the previously reported H 3 bpatcn (1-(carboxymethyl)-4,7-bis[(6-carboxypyridin-2-yl)methyl]-1,4,7-triazacyclononane) leads to an optimization of the properties of these gadolinium complexes. The replacement of an acetate binding group of the H 3 bpatcn ligand with a propionate group (H 3 ebpatcn) or a phosphonate group (H 4 pbpatcn) leads to a faster exchange rate of the coordinated water molecule in both mono-aquo gadolinium complexes. The resulting water exchange rate is optimized for the future design of high relaxivity macromolecular gadolinium

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Author

Aline Nonat; Marion Giraud; Christelle Gateau; Pascal H. Fries; Lothar Helm; Marinella Mazzanti

Publisher

Royal Society of Chemistry (RSC)

Published

2009

Language

EN

Field

Chemistry (Physical Sciences)