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Evaluation of a clinical screening tool for HIV-associated sensory neuropathies by C. L. Cherry; S. L. Wesselingh; L. Lal; J. C. McArthur is a Medicine article available to read on EtoBox.

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## Objective: To evaluate the performance characteristics of a brief clinical neuropathy screening tool for use in sensory neuropathies complicating hiv infection. ## Methods: The authors assessed 80 patients using the brief peripheral neuropathy screen (bpns). patients were defined as having neuropathy if they had both symptoms and signs consistent with this diagnosis. all subjects underwent sensory threshold testing and lower limb epidermal nerve fiber quantification using punch skin biopsy as objective measures. ## Results: Individuals defined as having neuropathy using the bpns (n = 37) performed less well on sensory threshold testing than other hiv-infected individuals (p < 0.0001 for warming, cooling, and vibration) and also had lower distal calf epidermal nerve fiber densities (p < 0.0001). individuals who had symptoms but no neuropathic signs (n = 13) did not perform differently on any objective testing compared with neuropathy-free individuals, supporting the decision to require signs as well as symptoms as an operational criterion for the diagnosis of neuropathy. of the symptoms listed in the screening tool, the presence of numbness had the greatest diagnostic efficiency

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Author

C. L. Cherry; S. L. Wesselingh; L. Lal; J. C. McArthur

Publisher

Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer) - American Academy of Neurology; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0028-3878)

Published

2005

Language

EN

Field

Medicine (Health Sciences)