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Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N ‐acetyl‐L‐cysteine by Carolyn A. Harris; James H. Resau; Eric A. Hudson; Richard A. West; Candice Moon; Andrew D. Black; James P. McAllister II is a Engineering article available to read on EtoBox.
What is Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N ‐acetyl‐L‐cysteine about?
## Abstract Cellular obstruction of poly(dimethyl)siloxane (PDMS) catheters is one of the most prevalent causes of shunt failure in the treatment of hydrocephalus. By modifying PDMS using short‐ and long‐chain mono‐functional polyethylene glycol (PEG604 and PEG5K, respectively) and __N__‐acetyl‐L‐cysteine via adsorption and covalent binding (NAC and NAC/EDC/NHS, respectively), we increased surface wettability. We hypothesized that these surface modifications would inhibit protein adsorption and decrease host macrophage and astrocyte adhesion. Tested in a bioreactor set to mimic physiological flow, all modified surfaces significantly decreased albumin adsorption compared with PDMS (__p__ < 0.05) except for PEG604‐modified PDMS (__p__ = 0.14). All four modification strategies significantly reduced (__p__ < 0.01) fibronectin adsorption. PEG604, PEG5K, NAC, and NAC/EDC/NHS reduced the average level of macrophage adhesion by 53%, 63%, 40%, and 58% (__p__ <.0.05 except when comparing PDMS with NAC) and astrocyte adhesion by 47%, 83%, 91%, and 72% (__p__ < 0.05 except when comparing PDMS with PEG604), respectively. Combined with saline soak results which suggest that the surface wettabili
Who reads Reduction of protein adsorption and macrophage and astrocyte adhesion on ventricular catheters by polyethylene glycol and N ‐acetyl‐L‐cysteine?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Carolyn A. Harris; James H. Resau; Eric A. Hudson; Richard A. West; Candice Moon; Andrew D. Black; James P. McAllister II
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)
- Published
- 2011
- Language
- EN
- Field
- Engineering (Physical Sciences)