Opening book details…
Can I read CD1c Presentation of Synthetic Glycolipid Antigens with Foreign Alkyl Branching Motifs on EtoBox?
CD1c Presentation of Synthetic Glycolipid Antigens with Foreign Alkyl Branching Motifs by Annemieke de Jong; Eva Casas Arce; Tan-Yun Cheng; Ruben P. van Summeren; Ben L. Feringa; Vadim Dudkin; David Crich; Isamu Matsunaga; Adriaan J. Minnaard; D. Branch Moody is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is CD1c Presentation of Synthetic Glycolipid Antigens with Foreign Alkyl Branching Motifs about?
Human CD1c is a protein that activates ab T cells by presenting self antigens, synthetic mannosyl phosphodolichols, and mycobacterial mannosyl phosphopolyketides. To determine which molecular features of antigen structure confer a T cell response, we measured activation by structurally divergent Mycobacterium tuberculosis mannosyl-b1-phosphomycoketides and synthetic analogs with either stereorandom or stereospecific methyl branching patterns. T cell responses required both a phosphate and a b-linked mannose unit, and they showed preference for C 30-34 lipid units with methyl branches in the S-configuration. Thus, T cell responses were strongest for synthetic compounds that mimicked the natural branched lipids produced by mycobacterial polyketide synthase 12. Incorporation of methylmalonate to form branched lipids is a common bacterial lipid-synthesis pathway that is absent in vertebrates. Therefore, the preferential recognition of branched lipids may represent a new lipidbased pathogen-associated molecular pattern.
Who reads CD1c Presentation of Synthetic Glycolipid Antigens with Foreign Alkyl Branching Motifs?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Annemieke de Jong; Eva Casas Arce; Tan-Yun Cheng; Ruben P. van Summeren; Ben L. Feringa; Vadim Dudkin; David Crich; Isamu Matsunaga; Adriaan J. Minnaard; D. Branch Moody
- Publisher
- Elsevier Science; Elsevier ; Cell Press; Elsevier BV (ISSN 1074-5521)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)