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Can I read On the Influence of Mechanical Conditions in Osteochondral Defect Healing on EtoBox?
On the Influence of Mechanical Conditions in Osteochondral Defect Healing by Georg N. Duda; Zully M. Maldonado; Petra Klein; Markus O.W. Heller; Justin Burns; Hermann Bail is a Medicine article available to read on EtoBox.
What is On the Influence of Mechanical Conditions in Osteochondral Defect Healing about?
Despite the introduction of new surgical techniques, the treatment of cartilage defects remains challenging. Delay or complete failure of cartilage healing is associated with problems in biological regeneration. The influence of mechanical conditions on this process, however, remains unevaluated. Osteochondral defects were generated on the left femoral condyle in 18 Yucatan minipigs. After 4, 6 and 12 weeks the defect filling, trabecular orientation and bone density were compared to the intact contralateral side. The mechanical straining during this period was then analyzed using an adaptive finite element technique. Histologically, the osteochondral defects showed bone resorption at the base and bone formation from the circumference. At 12 weeks, the macroscopically healed specimens showed fibrous cartilage formation, a minimally organized trabecular structure and increased trabecular volume fraction compared to the controls (po0:002). The amount of cancellous, cartilagineous, and fibrous tissue and the defect size as measured in histomorphometric analysis for the three time points (4, 6 and 12 weeks) was comparable in magnitude to that predicted by finite element analysis. The si
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- Author
- Georg N. Duda; Zully M. Maldonado; Petra Klein; Markus O.W. Heller; Justin Burns; Hermann Bail
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0021-9290)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)