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This study investigates the renal expression and urinary excretion of organic anion transporter 5 (Oat5) in rats treated with varying doses of cisplatin, a chemotherapy drug known for its nephrotoxic effects. The findings suggest that increased urinary Oat5 levels may serve as a non-invasive early biomarker for cisplatin-induced acute kidney injury, even before traditional renal injury markers show changes. The results indicate a dose-dependent relationship between cisplatin administration and Oat5 expressi
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