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Can I read The Systemic Effect of Intraarticular Administration of Corticosteroid on Markers of Bone Formation and Bone Resorption in Patients with Rheumatoid Arthritis on EtoBox?
The Systemic Effect of Intraarticular Administration of Corticosteroid on Markers of Bone Formation and Bone Resorption in Patients with Rheumatoid Arthritis by Ronald D. Emkey; Robert Lindsay; Jane Lyssy; Jerome S. Weisberg; David W. Dempster; Victor Shen is a Medicine article available to read on EtoBox.
What is The Systemic Effect of Intraarticular Administration of Corticosteroid on Markers of Bone Formation and Bone Resorption in Patients with Rheumatoid Arthritis about?
## Objective. To assess the effects of intraarticular (IA) corticosteroid use on bone metabolism in patients with rheumatoid arthritis (RA). Methods. Levels of the bone turnover markers, serum osteocalcin (BGP) and urinary pyridinoline (PYD), were monitored in RA patients for 4 weeks following a single IA administration of xylocaine alone or in combination with triamcinolone acetonide. Results. Levels of the bone resorption marker, PYD, did not show any significant change, whereas BGP levels were drastically decreased 1 day after IA administration of corticosteroid, and then returned to pretreatment levels by day 14. The efficacy of IA corticosteroid treatment lasted for 4 weeks. ## Conclusion. Our results suggest that IA administration of corticosteroid has no net effects on bone resorption and only a transient systemic effect on bone formation. IA corticosteroid administration may be better for bone metabolism than continuous use of orally administered corticosteroid. The antiinflammatory and immunosuppressive properties of glucocorticosteroids have prompted their extensive use in treating various diseases, including rheumatoid arthritis (RA). However, prolonged use of oral corti
Who reads The Systemic Effect of Intraarticular Administration of Corticosteroid on Markers of Bone Formation and Bone Resorption in Patients with Rheumatoid Arthritis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ronald D. Emkey; Robert Lindsay; Jane Lyssy; Jerome S. Weisberg; David W. Dempster; Victor Shen
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)