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Can I read Peroxynitrite Plays a Role in Methamphetamine-induced Dopaminergic Neurotoxicity: Evidence from Mice Lacking Neuronal Nitric Oxide Synthase Gene or Overexpressing Copper–zinc Superoxide Dismutase on EtoBox?
Peroxynitrite Plays a Role in Methamphetamine-induced Dopaminergic Neurotoxicity: Evidence from Mice Lacking Neuronal Nitric Oxide Synthase Gene or Overexpressing Copper–zinc Superoxide Dismutase by Syed Z. Imam; Glenn D. Newport; Yossef Itzhak; Jean L. Cadet; Fakhrul Islam; William Slikker Jr; Syed F. Ali is a Neuroscience article available to read on EtoBox.
What is Peroxynitrite Plays a Role in Methamphetamine-induced Dopaminergic Neurotoxicity: Evidence from Mice Lacking Neuronal Nitric Oxide Synthase Gene or Overexpressing Copper–zinc Superoxide Dismutase about?
The use of methamphetamine (METH) leads to neurotoxic effects in mammals. These neurotoxic effects appear to be related to the production of free radicals. To assess the role of peroxynitrite in METH‐induced dopaminergic, we investigated the production of 3‐nitrotyrosine (3‐NT) in the mouse striatum. The levels of 3‐NT increased in the striatum of wild‐type mice treated with multiple doses of METH (4 × 10 mg/kg, 2 h interval) as compared with the controls. However, no significant production of 3‐NT was observed either in the striata of neuronal nitric oxide synthase knockout mice (nNOS –/–) or copper–zinc superoxide dismutase overexpressed transgenic mice (SOD‐Tg) treated with similar doses of METH. The dopaminergic damage induced by METH treatment was also attenuated in nNOS–/– or SOD‐Tg mice. These data further confirm that METH causes its neurotoxic effects via the production of peroxynitrite.
Who reads Peroxynitrite Plays a Role in Methamphetamine-induced Dopaminergic Neurotoxicity: Evidence from Mice Lacking Neuronal Nitric Oxide Synthase Gene or Overexpressing Copper–zinc Superoxide Dismutase?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Syed Z. Imam; Glenn D. Newport; Yossef Itzhak; Jean L. Cadet; Fakhrul Islam; William Slikker Jr; Syed F. Ali
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)