Opening book details…
Can I read Gastrointestinal Toxicity and Its Relation to Dose Distributions in the Anorectal Region of Prostate Cancer Patients Treated with Radiotherapy on EtoBox?
Gastrointestinal Toxicity and Its Relation to Dose Distributions in the Anorectal Region of Prostate Cancer Patients Treated with Radiotherapy by Wilma D. Heemsbergen; Mischa S. Hoogeman; Guus A.M. Hart; Joos V. Lebesque; Peter C.M. Koper is a Medicine article available to read on EtoBox.
What is Gastrointestinal Toxicity and Its Relation to Dose Distributions in the Anorectal Region of Prostate Cancer Patients Treated with Radiotherapy about?
Purpose: To study the correlations between the dose distributions in the anorectal region and late GI symptoms in patients treated for localized prostate carcinoma. Methods and Materials: Data from a randomized study were analyzed. In this trial, patients were treated with either rectangular or conformal fields with a dose of 66 Gy. Data concerning GI symptoms were collected from questionnaires of 197 patients. The distributions of the anorectal region were projected on maps, and the dose parameters were calculated. The incidences of complaints were studied as a function of the dose-area parameters and clinical parameters, using a proportional hazard regression model. Finally, we tested a series of dose parameters originating from different parts of the anorectal region. Results: Analyzing the total region, only a statistically significant dose-area effect relation for bleeding was found (p < 0.01). Defining subareas, we found effect relations for bleeding, soiling, fecal incontinence, and mucus loss. For bleeding and mucus loss, the strongest correlation was found for the dose received by the upper 70 -80% of the anorectal region (p < 0.01). For soiling and fecal incontinence, we
Who reads Gastrointestinal Toxicity and Its Relation to Dose Distributions in the Anorectal Region of Prostate Cancer Patients Treated with Radiotherapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Wilma D. Heemsbergen; Mischa S. Hoogeman; Guus A.M. Hart; Joos V. Lebesque; Peter C.M. Koper
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)