Opening book details…
Can I read Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK—a randomized controlled trial on EtoBox?
Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK—a randomized controlled trial by Glenn Hernández; The ANDROMEDA-SHOCK Study Investigators; Alexandre Biasi Cavalcanti; Gustavo Ospina-Tascón; Fernando Godinho Zampieri; Arnaldo Dubin; F. Javier Hurtado; Gilberto Friedman; Ricardo Castro; Leyla Alegría; Maurizio Cecconi; Jean-Louis Teboul; Jan Bakker is a Medicine article available to read on EtoBox.
What is Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK—a randomized controlled trial about?
## Background: Septic shock is a highly lethal condition. early recognition of tissue hypoperfusion and its reversion are key factors for limiting progression to multiple organ dysfunction and death. lactate-targeted resuscitation is the gold-standard under current guidelines, although it has several pitfalls including that non-hypoxic sources of lactate might predominate in an unknown proportion of patients. peripheral perfusion-targeted resuscitation might provide a real-time response to increases in flow that could lead to a more timely decision to stop resuscitation, thus avoiding fluid overload and the risks of over-resuscitation. this article reports the rationale, study design and analysis plan of the andromeda-shock study. ## Methods: Andromeda-shock is a randomized controlled trial which aims to determine if a peripheral perfusion-targeted resuscitation is associated with lower 28-day mortality compared to a lactate-targeted resuscitation in patients with septic shock with less than 4 h of diagnosis. both groups will be treated with the same sequential approach during the 8-hour study period pursuing normalization of capillary refill time versus normalization or a decrease
Who reads Early goal-directed therapy using a physiological holistic view: the ANDROMEDA-SHOCK—a randomized controlled trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Glenn Hernández; The ANDROMEDA-SHOCK Study Investigators; Alexandre Biasi Cavalcanti; Gustavo Ospina-Tascón; Fernando Godinho Zampieri; Arnaldo Dubin; F. Javier Hurtado; Gilberto Friedman; Ricardo Castro; Leyla Alegría; Maurizio Cecconi; Jean-Louis Teboul; Jan Bakker
- Publisher
- Springer Science and Business Media LLC
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)