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GATD3A Deficiency and Osteoarthritis Progression by yuantaonjmu is a document available to read on EtoBox.
This study investigates the role of GATD3A deficiency in inducing mitochondrial dysfunction and cellular senescence in fibroblast-like synoviocytes (FLSs), which contributes to the progression of osteoarthritis (OA). The authors demonstrate that GATD3A downregulation leads to impaired tricarboxylic acid cycle activity and mitochondrial dysfunction, promoting FLS senescence and exacerbating OA symptoms. Therapeutic targeting of GATD3A may offer a novel approach to mitigate OA progression by restoring mitocho
- Author
- yuantaonjmu
- Language
- EN