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Basal Ganglia–premotor Dysfunction During Movement Imagination in Writer's Cramp by Florian Castrop; Christian Dresel; Andreas Hennenlotter; Claus Zimmer; Bernhard Haslinger is a Medicine article available to read on EtoBox.

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## Abstract The pathophysiology of idiopathic focal hand dystonia (writer's cramp) is characterized by deficient inhibitory basal ganglia function and altered cortical sensorimotor processing. To explore if this is already a primary finding in dystonia for internal movement simulation independent of dystonic motor output or abnormal sensory input, we investigated the neural correlates of movement imagination and observation in patients with writer's cramp. Event‐related fMRI was applied during kinesthetic motor imagery of drawing simple geometric figures (imagination task) and passively observing videos of hands drawing identical figures (observation task). Compared with healthy controls, patients with writer's cramp showed deficient activation of the left primary sensorimotor cortex, mesial and left dorsal premotor cortex, bilateral putamen, and bilateral thalamus during motor imagery. No significant signal differences between both groups were found during the observation task. We conclude that internal movement simulation and planning as tested during imagination of hand movements appear to be dysfunctional in patients with writer's cramp, whereas visual signal processing and obs

Who reads Basal Ganglia–premotor Dysfunction During Movement Imagination in Writer's Cramp?

Author

Florian Castrop; Christian Dresel; Andreas Hennenlotter; Claus Zimmer; Bernhard Haslinger

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2012

Language

EN

Field

Medicine (Health Sciences)