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Differential transient MEG and fMRI responses to visual stimulation onset rate by August S. Tuan; Rasmus M. Birn; Peter A. Bandettini; Geoffrey M. Boynton is a Computer Science article available to read on EtoBox.

What is Differential transient MEG and fMRI responses to visual stimulation onset rate about?

## Abstract While recent analysis of functional magnetic resonance imaging (fMRI) data utilize a generalized nonlinear convolution model (e.g., dynamic causal modeling), most conventional analyses of local responses utilize a linear convolution model (e.g., the general linear model). These models assume a linear relationship between the blood oxygenated level dependent (BOLD) signal and the underlying neuronal response. While previous studies have shown that this “neurovascular coupling” process is approximately linear, short stimulus durations are known to produce a larger fMRI response than expected from a linear system. This divergence from linearity between the stimulus time‐course and BOLD signal could be caused by neuronal onset and offset transients, rather than a nonlinearity in the hemodynamics related to BOLD contrast. We tested this hypothesis by measuring MEG and fMRI responses to stimuli with ramped contrast onsets and offsets in place of abrupt transitions. MEG results show that the ramp successfully reduced the transient onset of neural activity. However, the nonlinearity in the fMRI response, while also reduced, remained. Predictions of fMRI responses from MEG signa

Who reads Differential transient MEG and fMRI responses to visual stimulation onset rate?

Author

August S. Tuan; Rasmus M. Birn; Peter A. Bandettini; Geoffrey M. Boynton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-9457)

Published

2008

Language

EN

Field

Computer Science (Physical Sciences)