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Can I read A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer on EtoBox?
A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer by Robin J D Prestwich; Kiran Kancherla; Didem Colpan Oksuz; Deborah Williamson; Karen E Dyker; Catherine Coyle; Mehmet Sen is a Medicine article available to read on EtoBox.
What is A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer about?
## Background Chemo-radiotherapy offers an alternative to primary surgery and adjuvant therapy for the management of locally advanced stage IV squamous cell carcinomas of the tonsil. ## Methods A retrospective analysis was performed of the outcomes of 41 patients with locoregionally advanced squamous cell carcinoma of the tonsil treated non-surgically at the Yorkshire Cancer Centre between January 2004 and December 2005. Due to long radiotherapy waiting times, patients received induction chemotherapy with cisplatin and 5-fluorouracil followed by either cisplatin concurrent chemoradiotherapy or radiotherapy alone. ## Results Median age was 55 years (range 34-76 years) and 28 (68%) patients were male. 35/41 patients (85%) received 2 or more cycles of induction chemotherapy. Following induction chemotherapy, 32/41 patients (78%) had a clinical response. Concomitant chemotherapy was given to 30/41 (73%). All patients received the planned radiotherapy dose with no delays. There were no treatment related deaths. Six (15%) patients had gastrostomy tubes placed before treatment, and 22 (54%) required nasogastric tube placement during or after treatment for nutritional support. 17 patients
Who reads A single centre experience with sequential and concomitant chemoradiotherapy in locally advanced stage IV tonsillar cancer?
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- Author
- Robin J D Prestwich; Kiran Kancherla; Didem Colpan Oksuz; Deborah Williamson; Karen E Dyker; Catherine Coyle; Mehmet Sen
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2006-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1748-717X)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)