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Association of APOE ε2/ε3/ε4 and promoter gene variants with dementia but not cardiovascular mortality in old age by Bastiaan T. Heijmans; P. Eline Slagboom; Jacobijn Gussekloo; Simone Droog; A. Margot Lagaay; Cornelis Kluft; Dick L. Knook; Rudi G.J. Westendorp is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
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## Abstract The common apolipoprotein E (__APOE__) alleles ε2, ε3, and ε4 are associated with the risk of dementia and cardiovascular disease. Recently, two functional variants (− 219G/T and −491A/T) were identified in the promoter of the __APOE__ gene that enable a further characterization of the role of the __APOE__ locus in disease. We investigated the contribution of these __APOE__ gene variants to dementia and cardiovascular mortality in old age using a population‐based cohort of 648 subjects aged 85 years and over (Leiden 85‐Plus Study). Genotypes containing an __APOE__ ε4 allele were associated with a 4.1‐fold (95% CI, 2.2–7.7) increased risk of dementia as compared to the ε3/ε3 genotype in old subjects. Moreover, homozygosity for the −219T allele was found to be associated with a 2.4‐fold (95% CI, 1.0–5.8) increased risk independently of ε2 and ε4; the −491A/T variant was not associated with dementia. Over a 10‐year follow‐up period, the risk of cardiovascular mortality was not increased among ε4 carriers (RR, 0.6; 95% CI, 0.4–1.0) or −219T homozygous subjects (RR, 1.1; 95% CI, 0.7–1.7), nor did it decrease among −491T homozygous subjects (RR, 1.4; 95% CI, 0.6–3.1). In conc
Who reads Association of APOE ε2/ε3/ε4 and promoter gene variants with dementia but not cardiovascular mortality in old age?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Bastiaan T. Heijmans; P. Eline Slagboom; Jacobijn Gussekloo; Simone Droog; A. Margot Lagaay; Cornelis Kluft; Dick L. Knook; Rudi G.J. Westendorp
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0148-7299)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)