Can I read Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank on EtoBox?

Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank by Yu Jia; Dongze Li; Yi You; Jing Yu; Wenli Jiang; Yi Liu; Rui Zeng; Zhi Wan; Yi Lei; Xiaoyang Liao is a Medicine article available to read on EtoBox.

What is Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank about?

## Background Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly defined condition encompassing hepatic steatosis and metabolic dysfunction. However, the relationship between MAFLD and multi-system diseases remains unclear, and the time-dependent sequence of these diseases requires further clarification. ## Methods After propensity score matching, 163,303 MAFLD subjects and 163,303 matched subjects were included in the community-based UK Biobank study. The International Classification of Diseases, Tenth Revision (ICD-10), was used to reclassify medical conditions into 490 and 16 specific causes of death. We conducted a disease trajectory analysis to map the key pathways linking MAFLD to various health conditions, providing an overview of their interconnections. ## Results Participants aged 59 (51–64) years, predominantly males (62.5%), were included in the study. During the 12.9-year follow-up period, MAFLD participants were found to have a higher risk of 113 medical conditions and eight causes of death, determined through phenome-wide association analysis using Cox regression models. Temporal disease trajectories of MAFLD were established using disease pairing

Who reads Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease: findings from the UK Biobank?

Author

Yu Jia; Dongze Li; Yi You; Jing Yu; Wenli Jiang; Yi Liu; Rui Zeng; Zhi Wan; Yi Lei; Xiaoyang Liao

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)