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1 s2.0 S2451945626000760 mmc4 by AsakuraHao is a document available to read on EtoBox.
Sato et al. present high-resolution structures of the helicase-primase complex (HPC) from human herpesvirus 1, revealing how inhibitors amenamevir and pritelivir bind to a shared allosteric pocket, locking the helicase in an inactive state. This study clarifies the structural basis for drug specificity within the α-subfamily of herpesviruses and provides insights for developing novel antivirals targeting a broader range of herpesviruses. The findings establish a framework for rational drug design aimed at e
- Author
- AsakuraHao
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- EN