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LncRNA NEAT1_1 suppresses tumor-like biologic behaviors of fibroblast-like synoviocytes by targeting the miR-221-3p/uPAR axis in rheumatoid arthritis by Manli Wang; Yixiong Chen; Xuan Bi; Xiqing Luo; Zuoyu Hu; Yan Liu; Xiaoyi Shi; Weizhen Weng; Biyao Mo; Yan Lu; Yunfeng Pan is a Immunology and Microbiology article available to read on EtoBox.
What is LncRNA NEAT1_1 suppresses tumor-like biologic behaviors of fibroblast-like synoviocytes by targeting the miR-221-3p/uPAR axis in rheumatoid arthritis about?
## Abstract Fibroblast-like synoviocytes (FLSs) are the predominant effector cells in the pathological progression of rheumatoid arthritis (RA). Therefore, elucidating the underlying molecular mechanism of the biologic behaviors in RA-FLSs will be helpful in developing the potent targets for the treatment of RA. We have previously documented that the tumor-like biologic behaviors of RA-FLSs are exacerbated by urokinase-type plasminogen activator receptor (uPAR), a specifically up-regulated receptor in RA-FLSs. Here, we investigate the further mechanism of uPAR and clarify its function in RA-FLSs. We demonstrate that miR-221-3p positively correlates to uPAR and regulates uPAR level in RA-FLSs. Simultaneously, one long noncoding RNA, nuclear paraspeckle assembly transcript 1\_1 (NEAT1\_1) is identified, which can predictively target miR-221-3p at three sites, indicating a strong possibility of being a competing endogenous RNA in RA-FLSs. Interestingly, NEAT1\_1 and miR-221-3p can colocate in the nucleus and cytoplasm in RA-FLSs. Importantly, NEAT1\_1 can act as a rheostat for the miR-221-3p/uPAR axis and the downstream JAK signaling. In line with the biologic function, NEAT1\_1 negat
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- Author
- Manli Wang; Yixiong Chen; Xuan Bi; Xiqing Luo; Zuoyu Hu; Yan Liu; Xiaoyi Shi; Weizhen Weng; Biyao Mo; Yan Lu; Yunfeng Pan
- Publisher
- Oxford University Press (OUP)
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)