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The study investigates the effects of Shiga toxin 1 (Stx1) and lipopolysaccharide (LPS) on astrocytes (ASTs) and their subsequent impact on brain endothelial cells (ECs) in the context of hemolytic uremic syndrome (HUS). It demonstrates that ASTs activated by Stx1 and LPS release factors that compromise the integrity of the blood-brain barrier (BBB) and enhance the susceptibility of ECs to Stx1 toxicity, potentially contributing to neurological complications in HUS. The findings suggest that the inflammator

Author

kulczyk.anya

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EN