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Evaluating the Efficacy of a Combination Therapy by Steven M. Snapinn is a Mathematics article available to read on EtoBox.
What is Evaluating the Efficacy of a Combination Therapy about?
Standard multiple comparison techniques do not adequately address the situation in which one must demonstrate a combination therapy's superiority to both of its components. This paper proposes several alternative tests to deal with this situation, and evaluates the tests with a Monte Carlo sampling experiment that compares the actual with the nominal significance levels of the tests. Data from a clinical trial that compares the efficacy of a combination analgesic/muscle relaxant to its components and placebo in the treatment of low back pain and spasm illustrate the tests. KEY WORDS Multiple comparisons Monte Carlo sampling Low back pain and spasm ## Introduction Two or more standard therapies for a disease or condition sometimes combine to produce a new therapy superior to its components. To achieve approval for use in the United States of America, a new combination drug must satisfy the Food and Drug Administration's requirement that each component makes a contribution to the claimed effects of the combination. The requirements, however, do not specify the statistical methods to be used, and standard statistical methods, including ordinary multiple comparison techniques, do not a
Who reads Evaluating the Efficacy of a Combination Therapy?
It is typically read by researchers, students, and practitioners in Mathematics.
- Author
- Steven M. Snapinn
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0277-6715)
- Published
- 1987
- Language
- EN
- Field
- Mathematics (Physical Sciences)