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Periarticular Proprioception: Analyzing the Three-dimensional Structure of Corpuscular Mechanosensors in the Dorsal Part of the Scapholunate Ligament by Rami Al Meklef; Johannes Kacza; Thomas Kremer; Susanne Rein is a Medicine article available to read on EtoBox.

What is Periarticular Proprioception: Analyzing the Three-dimensional Structure of Corpuscular Mechanosensors in the Dorsal Part of the Scapholunate Ligament about?

Introduction Sensory nerve endings transmit mechanical stimuli into afferent neural signals and form the basis of proprioception, giving rise to the self-perception of dynamic stability of joints. We aimed to analyze the three-dimensional structure of periarticular corpuscular sensory nerve endings in a carpal ligament to enhance our understanding of their microstructure. Methods Two dorsal parts of the scapholunate ligament were excised from two human cadaveric wrist specimens. Consecutive cryosections were stained with immunofluorescence markers protein S100B, neurotrophin receptor p75 (p75), protein gene product 9.5 (PGP 9.5) and 4′ ,6-diamidino-2-phenylindole (DAPI). Three-dimensional images of sensory nerve endings were obtained using confocal laser scanning microscopy and subsequent analysis was performed using Imaris software. Results Ruffini endings were characterized by a PGP 9.5-positive central axon, with a median diameter of 4.63 μm and contained a median of 25 cells. The p75-positive capsule had a range in thickness of 0.94 μm and 15.5 μm, consisting of single to three layers of lamellar cells. Ruffini endings were significantly smaller in volume than Pacini corpuscles

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Author

Rami Al Meklef; Johannes Kacza; Thomas Kremer; Susanne Rein

Publisher

S. Karger AG

Published

2024

Language

EN

Field

Medicine (Health Sciences)